An iridium(iii)-based irreversible protein–protein interaction inhibitor of BRD4 as a potent anticancer agent† †Electronic supplementary information (ESI) available: Synthetic methods, characterization and biological assays details. See DOI: 10.1039/c5sc02321a Click here for additional data file.

State Key Laboratory of Quality Research i Medical Sciences, University of Macau, Ma mo Department of Chemistry, Hong Kong Bapti China. E-mail: [email protected] National Center for Protein Science Shangh Institute of Biochemistry and Cell Biolo Sciences, Chinese Academy of Sciences, Sha Department of Applied Biology and Chemica University, Hung Hom, Kowloon, Hong Kon Partner State Key Laboratory of Environmen Chemistry, Hong Kong Baptist University, 2 Kong SAR, P. R. China. E-mail: zwcai@hkbu Department of Fragrance and Cosmetic Kaohsiung 807, Taiwan, Republic of China. Graduate Institute of Natural Products, K 807, Taiwan, Republic of China † Electronic supplementary information characterization and biological assays det ‡ These authors contributed equally to th Cite this: Chem. Sci., 2015, 6, 5400